Curtis appeared in supporting roles or in ensemble casts during the early part of her career, with most of her early TV shows airing on the GMA-7 Network in the Philippines in where she starred in shows like Love to Love, where she was partnered with Richard Gutierrez.

In 2004, when she moved to ABS-CBN, Curtis received her first big break in Philippine primetime TV when she was cast in the role of Stephanie Borromeo in the TV series Hiram as the best friend and romantic rival of Margaret Benipayo, portrayed by Heart Evangelista. The role was a departure from her earlier, typical, teeny-bopper roles, and positioned Curtis for primetime.

In 2005, her successful portrayal in Hiram led to her first title role as Imang/Fatima in the fantasy TV series Kampanerang Kuba.^[1]

In 2006 Curtis returned to primetime TV as Celine Magsaysay in drama series Maging Sino Ka Man, this time with new love team partner Sam Milby. In 2007 She became a part of MTV as a VJ on Gimme 10. In 2008 she starred When Love Begins. Currently, she plays a goddess in the fantasy series Dyosa. The next Anne will see in a period movie Baler an official entry to MMFF, her leading man is Jericho Rosales.